Wegovy Tablets Side Effects: Complete Guide

Wegovy Tablets Side Effects: Complete Guide

As of October 2026, Wegovy is no longer just an injection-only conversation. The U.S. FDA approved Wegovy tablets, a once-daily oral semaglutide (maintenance dose 25 mg), on December 22, 2025, and the FDA label covers both the tablets and the injection.

That means a side-effects guide for Wegovy tablets should talk about a real, approved product rather than a hypothetical future formulation. Consult your healthcare provider before starting any medication.

What are Wegovy tablets?

Wegovy tablets contain semaglutide, a GLP-1 receptor agonist. Like injectable Wegovy, they are used in weight-management discussions because semaglutide can reduce appetite, increase fullness, and slow gastric emptying.

The tablet format changes the day-to-day routine, but it does not remove the need to watch for semaglutide-related side effects.

Common side effects of Wegovy tablets

The most common side effects are still mainly gastrointestinal. These often show up most strongly when starting treatment or moving up in dose.

Nausea

Nausea is one of the most common semaglutide side effects. It may feel like mild queasiness or more persistent discomfort.

Vomiting

Some people also experience vomiting, especially during early dose escalation.

Diarrhoea

Loose stools or more frequent bowel movements can happen as your body adjusts.

Constipation

Other people notice the opposite pattern, with slower bowel movements or constipation.

Abdominal pain, bloating, or gas

Because semaglutide slows stomach emptying, some users report abdominal discomfort, bloating, burping, or a heavy/full feeling after meals.

Other side effects that can happen

Beyond the digestive system, some patients report:

• headache
• tiredness or fatigue
• dizziness
• reduced appetite beyond what they expected

Why side effects happen

Many of these effects are linked to how semaglutide works. It affects appetite signaling and slows the rate at which food leaves the stomach. That mechanism can be helpful for weight management, but it also explains why digestive side effects are so common.

Serious but less common side effects

Like other semaglutide products, Wegovy tablets can also raise concern for more serious problems that need prompt medical attention.

Pancreatitis

Seek urgent medical advice if you develop severe stomach pain that does not go away, especially if it spreads to your back.

Gallbladder problems

Warning signs can include upper-abdominal pain, fever, nausea, vomiting, or yellowing of the skin or eyes.

Kidney problems from dehydration

Persistent vomiting or diarrhoea can lead to dehydration, which may worsen kidney function.

Serious allergic reactions

Get urgent help if you develop swelling of the face, lips, tongue, or throat, trouble breathing, or a severe rash.

Low blood sugar

The risk of low blood sugar rises if you also take insulin or a sulfonylurea. Your prescriber may lower the dose of those medicines. Shakiness, sweating, confusion and a fast heartbeat are warning signs.

Vision changes in people with diabetes

In people with type 2 diabetes and diabetic eye disease (retinopathy), semaglutide has been linked to retinopathy complications. Tell your clinician about any change in your vision.

Mood changes

The label advises monitoring for depression or suicidal thoughts. Tell your clinician about new or worsening low mood, and get urgent help if you have thoughts of harming yourself.

Surgery and sedation

Semaglutide slows stomach emptying, which can raise the risk of inhaling stomach contents under general anaesthesia or deep sedation. Tell your care team that you take Wegovy tablets before any procedure.

Pregnancy

Semaglutide may harm an unborn baby. The label advises stopping when pregnancy is recognised and at least 2 months before a planned pregnancy. Talk to your prescriber if you are planning a pregnancy.

Thyroid tumor warning

Semaglutide products carry a boxed warning based on rodent studies about possible thyroid C-cell tumors. Wegovy tablets should not be used by anyone with a personal or family history of medullary thyroid carcinoma or MEN 2. Tell your clinician about a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath.

Tips to discuss with your clinician

Many people do better when they:

• eat smaller meals
• avoid large, greasy, or very rich meals when nausea is active
• stay hydrated
• report persistent vomiting, constipation, or abdominal pain early
• avoid making dose changes on their own (the label says to skip a missed tablet and take the next one the following day, and never take more than one tablet a day)

When to contact your clinician

Reach out if:

• side effects are severe or do not settle
• you cannot keep fluids down
• you notice yellowing of the skin or eyes
• you are thinking about stopping treatment because of side effects

Seek urgent medical help (emergency care) for severe stomach pain that does not go away, especially if it spreads to your back, or for swelling of the face, lips, tongue or throat or trouble breathing.

Bottom line

Wegovy tablets are now a real oral semaglutide product, so their side-effect guide should be grounded in current tablet status. The most common issues are still gastrointestinal—especially nausea, vomiting, diarrhoea, constipation, and abdominal discomfort—but serious warning symptoms still matter and should be reviewed with a clinician.

That conversation is the safest way to weigh whether the tablet form fits your treatment goals and tolerance. Consult your healthcare provider before starting any medication.

Sources

• https://www.wegovy.com/
• Wegovy (injection and tablets) prescribing information, U.S. FDA: https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/218316Orig1s000lbl.pdf
• https://medlineplus.gov/druginfo/meds/a619057.html
• OASIS 4: Wharton S, et al. Oral semaglutide at a dose of 25 mg in adults with overweight or obesity. N Engl J Med. 2025;393(11):1077-1087. doi:10.1056/NEJMoa2500969