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GLP-1 side effects day by day: is what I'm feeling normal?
For people already prescribed GLP-1 medication. Weight Easy does not prescribe, sell or arrange medication. Your prescriber makes treatment and dose decisions.
By the Weight Easy Editorial Team ·
✓ Free to download
Quick answer: Nausea, vomiting, diarrhoea, reflux and sulphur burps are most common 1 to 3 days after a GLP-1 injection and in the first 1 to 2 weeks after a dose increase. Constipation tends to build later in the week. Most stomach side effects ease over time, but severe stomach pain, signs of dehydration or yellow skin need a doctor straight away.
Weekly injections
- Mounjaro (tirzepatide)
- Zepbound (tirzepatide)
- Ozempic (semaglutide)
- Wegovy (semaglutide)
- Generic semaglutide for diabetes (Obeda, Sematrinity, GLIPIQ)
- Generic semaglutide for weight (Noveltreat)
- Yurpeak (tirzepatide)
- Compounded semaglutide
- Compounded tirzepatide
- Trulicity (dulaglutide)
- Bydureon BCise (exenatide extended-release)
Daily injections
- Saxenda (liraglutide)
- Victoza or generic liraglutide
- Byetta (exenatide)
Daily tablets
- Wegovy pill (oral semaglutide)
- Rybelsus 1.5, 4 or 9 mg, or Ozempic tablets (oral semaglutide)
- Rybelsus 3, 7 or 14 mg (oral semaglutide)
- Foundayo (orforglipron)
- Day 1 (shot day)
- Day 2
- Day 3
- Day 4
- Day 5
- Day 6
- Day 7
Day 1 is injection day.
Fill in the form to see what’s typical and what helps
Still needed: your medication, days since your injection, at least one symptom.
Get medical help straight away if you have:
- Severe stomach pain that won't go away, with or without vomiting, sometimes spreading to your back (possible pancreatitis).
- Pain in the upper right belly, fever, yellow skin or eyes, or pale stools (possible gallbladder problem).
- Vomiting or diarrhoea so you can't keep fluids down, very little urine, or feeling faint (dehydration).
- Swelling of the face, lips or throat, trouble breathing, or a severe rash (allergic reaction).
- Shakiness, sweating, confusion or a fast heartbeat if you also take insulin or a sulfonylurea (low blood sugar).
- A lump or swelling in your neck, trouble swallowing or a hoarse voice that doesn't go away.
- New or worsening low mood or thoughts of harming yourself.
Works with: Mounjaro, Zepbound, Ozempic, Wegovy, Wegovy pill, Rybelsus, Ozempic tablets, Saxenda, Victoza, Trulicity, Bydureon BCise, Byetta, Foundayo, Yurpeak, Obeda, Noveltreat, Semaglyn, Sematrinity, GLIPIQ, compounded semaglutide, compounded tirzepatide.
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Log a symptom, get help that knows your week
In Weight Easy you log how you feel in seconds. Weight Easy's AI coach links it to your dose and cycle day, suggests home remedies that fit, and shows patterns you can take to your doctor.
- Symptom log tied to your dose and cycle day
- Home remedies matched to what you feel
- Patterns over weeks, ready for your doctor
- Meals that go easier on bad days
Free to download. Subscription for full features, with a 7-day free trial on the yearly plan. For people already prescribed GLP-1 medicine. Weight Easy does not prescribe, sell or arrange medicine. Follow the treatment instructions from your prescribing clinician.
Read the complete guide
The calculator stays free on this page. Its longer explanatory article, medicine-specific FAQ and cited sources live in the Weight Easy blog, alongside the other health and tracking guides.
Read the guide and FAQ →Related guides
- How to Manage Side Effects on MounjaroUnderstand typical side effects of Mounjaro, strategies for management, and guidance on when to contact a healthcare provider.
- How to Manage Side Effects on OzempicExplore common side effects of Ozempic, tips for managing them, and advice on when to reach out to a healthcare professional.
- A Practical Week-by-Week Way to Track Wegovy Side EffectsUse a simple week-by-week framework to track Wegovy side effects, notice patterns early, and prepare more useful check-ins with your clinician.
- Ozempic Constipation: Why It Happens and 8 Remedies That HelpDiscover reasons for constipation with Ozempic and explore eight remedies that may help alleviate this side effect.
- GLP-1 Drugs and Gallbladder Problems: What the Research ShowsExplore research on the relationship between GLP-1 drugs and gallbladder issues, with information on what is currently known.
Sources and limits
- Ozempic, Wegovy, Mounjaro and Zepbound prescribing information: adverse reactions and warnings sections.
- Timing guidance reflects common patient experience and label information; individual experience varies.
This tool is for education. It does not diagnose, prescribe or change a dose. Always follow your prescriber and the leaflet that came with your medication.