Missed your GLP-1 dose? Take it now or skip it

Missed dose rules by medication

These rules come from each medicine's label. Your leaflet and your prescriber come first.

• Mounjaro and Zepbound (tirzepatide): take within 4 days (96 hours) of the missed dose; otherwise skip it.
• Ozempic (semaglutide): take within 5 days of the missed dose; otherwise skip it.
• Wegovy in the UK and EU: take within 5 days of the missed dose; otherwise skip it.
• Wegovy in the US: take it if the next scheduled dose is more than 2 days (48 hours) away; otherwise skip it. If you miss 2 or more doses in a row, the US label says to restart the dose steps at a lower dose; the UK and EU label says a lower restart dose should be considered if more than one dose is missed.
• Generic semaglutide in India (Obeda, Sematrinity, GLIPIQ, Noveltreat, Semaglyn and others) and compounded semaglutide: follow your pack leaflet. The brands haven't published their own missed-dose rule, so this tool sends you to your leaflet or pharmacist and shows the Ozempic rule (diabetes pens) or Wegovy rule (Noveltreat) as a guide only.
• Yurpeak and compounded tirzepatide: follow your pack leaflet or pharmacy. As a guide, the Mounjaro rule is 4 days (96 hours).
• Trulicity and Bydureon BCise: take it if the next dose is at least 3 days (72 hours) away; otherwise skip it.
• Saxenda and Victoza (liraglutide, daily): in the US, skip the missed dose, and if more than 3 days have passed since your last dose, the US label says to restart at 0.6 mg. In the UK and EU, take it if within 12 hours of your usual time, otherwise skip it; the UK and EU labels have no restart rule.
• Byetta (twice daily): skip the missed dose and take the next one as usual.
• Rybelsus and the Wegovy pill (daily tablets): skip the missed tablet and take the next one the following day.
• Foundayo (daily tablet): take it as soon as you remember; never two on the same day. On the US label, after 7 or more missed days in a row, restart the dose steps.

If you've missed two weeks or more

After a longer gap, your body loses some of its tolerance to the medicine. Going straight back to your usual dose can bring back strong nausea and vomiting, so contact your prescriber first. Many people are restarted at a lower dose and stepped back up.

Changing your injection day

You can move your weekly injection day as long as there are at least 3 days (72 hours) between doses for Mounjaro, Zepbound, Trulicity and Bydureon BCise. Ozempic needs more than 2 days (48 hours) in the US and more than 3 days (72 hours) in the UK and EU. For Wegovy, the US patient guide allows a new day if your last dose was 2 or more days before; the UK and EU label says more than 3 days (72 hours). After the change, keep the new day every week.

Travel, surgery and planned gaps

If you'll be travelling across time zones, keep your dose within the label window rather than worrying about the exact hour. Before surgery or procedures that need sedation, tell your care team you take a GLP-1, because they may ask you to pause it.

When to get help

If you took an extra dose by mistake, call your doctor or pharmacist for advice (in the US you can also call Poison Help on 1-800-222-1222; in the UK, call NHS 111). Get urgent medical help if you have severe stomach pain that won't go away (it may spread to your back), vomiting so bad you can't keep fluids down, signs of dehydration such as very little urine or dizziness, or signs of a serious allergic reaction such as swelling of the face or throat or trouble breathing. If you also take insulin or a sulfonylurea, watch for low blood sugar.